Doctor's Assessment Included
Every result includes a professional assessment from a BIG-registered doctor. For treatment decisions, discuss your results with your GP.
AMA (Anti-Mitochondrial Antibodies)
AMA testing screens for primary biliary cholangitis, an autoimmune liver condition that becomes more common with age. Early detection supports timely treatment and liver health preservation.
What It Measures
This test detects and quantifies anti-mitochondrial antibodies in your blood. A positive result, particularly the M2 subtype, is highly specific for primary biliary cholangitis.
Why It Matters
AMA positivity with elevated alkaline phosphatase is sufficient for PBC diagnosis in most cases, often without the need for liver biopsy. Early detection enables treatment to slow disease progression.
When to Test
Testing could be indicated when PBC is suspected: unexplained cholestatic liver enzyme elevation, chronic fatigue with pruritus, or as part of autoimmune liver disease evaluation.
Symptoms
Low Levels
A negative AMA result makes PBC unlikely but does not completely exclude it. A small percentage of PBC patients are AMA-negative.
High Levels
A positive AMA result strongly suggests PBC. Symptoms may include fatigue, pruritus (itching), dry eyes and mouth, and elevated liver enzymes. Some AMA-positive individuals remain asymptomatic for years.
Lifestyle Tips
If AMA-positive, consult a hepatologist for further evaluation. Avoid alcohol to protect liver function. Ursodeoxycholic acid (UDCA) is the standard treatment for PBC and can significantly slow disease progression when started early.
Frequently Asked Questions
Does a positive AMA always mean I have PBC?
AMA is highly specific for PBC but can rarely be found in other autoimmune conditions. Clinical correlation with liver enzymes and symptoms is important.
Can PBC be treated?
Yes. UDCA is effective in slowing disease progression in most patients. Early treatment significantly improves outcomes.
Is PBC hereditary?
PBC has a genetic component. First-degree relatives of PBC patients have a higher risk, though it is not directly inherited.